Ion-exchange chromatography coupled to multi-angle light scattering (IEX-MALS) allows absolute molar mass determination of proteins, protein complexes and peptides in a heterogenous sample. IEX-MALS can overcome some of the restrictions of SEC-MALS that arise from the limited separation ability of analytical SEC column. The IEX-MALS method is valuable for quality assessment as well as characterization of native oligomers, charge variants, modified proteins and mixed-protein samples.

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miniDAWN®

miniDAWN®

The Best in Basic Multi-Angle Light Scattering for Absolute Macromolecular Analysis.

The miniDAWN’s performance is exceeded only by the DAWN which covers a wider range of size and molecular weight, with even better sensitivity and additional optional modules.

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Optilab

Optilab

Universal Detection for Chromatography and FFF Separations

Using a combination of cutting-edge semiconductor photodiode technology and proprietary computer algorithms, the Optilab achieves an unprecedented combination of sensitivity and range. These features mean that it addresses both standard chromatographic applications and some challenges unique to light scattering measurements such as high concentrations, determination of sample refractive increments (dn/dc) and solvent refractive index.

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