Engineered Nanoparticles (ENPs) are of increasing importance to a diverse range of industrial and commercial products including pharmaceuticals, cosmetics and food. Whereas the physical properties of bulk materials remain constant regardless of their size, the size of nanoparticles often dictates their physical and chemical properties. Accurate and comprehensive characterization of nanoparticle size is therefore essential to controlling their properties and understanding their potential for new applications.

Additional parameters that are fundamental to nanoparticle development, optimization, formulation, toxicology and quality control include shape, zeta potential and aggregation. A variety of analytical techniques are available to address this parameter set, each with their own distinct advantages and disadvantages.

Eclipse AF4

Eclipse AF4

Versatile separations of polymers, proteins, colloids, and nanoparticles.

The Eclipse™ AF4 supports all AF4 techniques except Hollow-Fiber Flow Field-Flow Fractionation (HF5), which is covered by the Eclipse DualTec. However, the Eclipse AF4 supports the fritless AF4 channel which prevents the difficulties encountered by certain samples prone to aggregation at the relatively high concentrations typical of the AF4 focusing step. It also supports the semi-preparative channel.