Much attention has been paid to biodegradable nanoparticle systems. It is well known that parameters such as particle size and shape are important for blood circulation time. We used the methods of Photon Correlation Spectroscopy (PCS) and Asymmetrical Flow – Field Flow Fractionation (FFFF) to assess sizes of biodegradable nanoparticles.
The systems used were colloidal aqueous suspensions of nanospheres consisting of the biodegradable polyester Resomer RG 503 (0.5% w/v). The particles were produced using the solvent deposition method. To check the validity of the F-FFF method, particles with different sizes were produced by increasing the injection velocity of the acetone-polymer solution into the water.
