LC Sample Introduction – Lab Alliance http://staging.laballiance.com.my Technology That Matters Fri, 08 May 2020 10:27:20 +0000 en-US hourly 1 https://wordpress.org/?v=6.8.3 GERSTEL LC/MS Effluent Optimizer (LEO) http://staging.laballiance.com.my/product/gerstel-lc-ms-effluent-optimizer-leo/ Fri, 08 May 2020 10:25:44 +0000 http://staging.laballiance.com.my/?post_type=product&p=1131 Optimized LC separation and MS detection – the best of both worlds In LC/MS, we work hard to reach the goal of achieving the perfect LC separation and combining it with the most efficient ionization and lowest achievable MS detection limits for our analytes. The LC separation may require a certain pH and polarity range of the eluent, while analyte ionization in the LC/MS ionization source requires yet another pH, a different buffer – or even derivatization of the analyte for best possible efficiency or optimized spectral information. How to optimize both? The logical answer is to take the effluent from the perfect LC separation and optimize it for MS analysis.]]>

This task is easily possible when you add the GERSTEL LC/MS Effluent Optimizer (LEO) module to your LC/MS/MS system. Application examples show sensitivity gains of up to a factor of 40 by simply adding a salt solution to the LC effluent and/or changing its pH. The LEO module is quickly and easily installed in your LC/MS system. A solvent mixture, buffer solution or reagent is then easily added to the effluent ensuring that the LC separation can be performed under optimal conditions while also enabling maximum yield in the MS ionization process, helping to reduce or eliminate Ion Suppression. Whether you are looking to perform pH adjustment or post-column derivatization, for method development or routine analysis, when you use LEO you can easily and efficiently control all parameters as part of the overall software method. Just one sequence table controls the entire system from sample preparation through LC separation and effluent optimization to MS analysis. It is all done with the click of a mouse.

]]> Dynamic Load & Wash (DLW) – LC/MS Tool http://staging.laballiance.com.my/product/dynamic-load-wash-dlw-lc-ms-tool/ Fri, 08 May 2020 10:20:55 +0000 http://staging.laballiance.com.my/?post_type=product&p=1124 Near Zero Carryover – Fast Cycles and Exceptional Reproducibility Mass Spectrometers are continuously being improved and have become so sensitive that carryover is constantly an issue. To meet today’s requirements for fast, clean and reproducible LC/MS injection; GERSTEL is now offering the LC/MS-Tool for the GERSTEL MultiPurpose Sampler MPS robotic.]]>

With this option, the sample is no longer in contact with the syringe but it is aspirated into a holding loop/guard column located in front of the syringe. Even though the syringe acts only as an aspirating and dispensing device, it still provides the excellent reproducibility seen in standard syringe injection systems. After injection, the whole sample path including the valve and the needle is washed with up to 2 different solvents. Micro pumps deliver the required quantity of solvent quickly and reliably. At the end of the injection cycle, all parts which have been in contact with the sample are completely clean. As a result, near-zero carryover is achieved for most components.

LC/MS-Tool benefits:
  • Near zero carryover – Typically less than 0.003%
  • Fast – Cycle time between injections is less than a minute including cleaning step
  • Maestro control – Intrgrated software control including multiple sample preparation techniques
  • Reproducible – < 0.5% RSD
  • Two solvent wash – Complete cleaning from the opposite direction of sampling
  • Flexible – New 20,000 psi valve handles both HPLC and UHPLC applications
  • Modular – The LC/MS-Tool is easily added to existing MPS robotic series Autosamplers
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