Probe-in-probe:

The LF90II and LF110 feature a unique probe-in-probe solution developed to measure small samples, like newborn rodents, biopsies and other samples with premium sensitivity. The sensitivity is directly related to both, the filling factor of the probe and the probes quality factor. Thus, both factors have been designed for optimal performance combined with ease-of-use.

Reduced animal stress:

The BCA application with the minispec minimizes the animal stress because anesthesia is not required. More importantly, the animal stress is further reduced by use of the minispec proprietary red restrainers. It has been proven by experiment that rodents move freely into the restrainers, due to their dichromatic color perception, while the animal can be monitored all time.

Body Composition Analysis of Mice and Rats

Bruker’s minispec Whole Body Composition Analyzer based on TD-NMR provides a precise method for measurement of lean tissue, fat and fluid in living mice and rats.

This body composition analyzer boasts a novel and striking key feature: Because the animal is carefully handled without using any anesthetics, a new standard for longitudinal studies has been established.

Since its first launch in the beginning of 2001, the minispec Live Mice Analyzer (LF50) has quickly gained market acceptance as a powerful, non-destructive and non-invasive mice analysis tool for characterizing, screening and mouse phenotyping in research laboratories. It has become the industrial standard for fat and lean measurement in live mice with installations in major pharmaceutical companies, diabetes and obesity research institutes and universities.

Nuclear Magnetic Resonance (NMR) methods are among the most useful non-destructive techniques of material analysis. Non-invasive examination of the body by means of NMR is extensive and has many useful applications, particularly with Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS). TD-NMR uses similar NMR technology, providing analysis of fat tissue, lean tissue and free fluid by the same physical selection rules that give rise to contrast in MRI. Tissue contrast is high between fat and muscle based on relative relaxation times.

The minispec Body Composition Analyzer is based on Time Domain NMR. It acquires and analyzes TD-NMR signals from all protons in the entire sample volume and can provide 3 components of interest: Fat, Free Body Fluid and Lean Tissue values.

This Magnetic Resonance technology provides researchers with the opportunity to make multiple measurements during the life of the animal with the following benefits:

• Rapid analysis: measurement takes less than 2 minutes, no sample preparation
• Economical procedures: no consumables, retain expensive lab animals for entire study
• LF50 for mice analyzes animals up to 60 g
• LF50H for mice analyzes animals up to 60 g
• LF90II for mice and rats analyzes animals up to ~ 700 g
• LF110 for mice and rats analyzes animals up to approximately 1 kg
• Reduced animal stress: no need for anesthetics; animals are measured “as-is”
• Allows more frequent testing, due to reduction of risks to animal health
• Better accuracy and precision compared to DEXA (X-ray) method

Body Composition Analysis of Mice and Rats

Bruker’s minispec Whole Body Composition Analyzer based on TD-NMR provides a precise method for measurement of lean tissue, fat and fluid in living mice and rats.

This body composition analyzer boasts a novel and striking key feature: Because the animal is carefully handled without using any anesthetics, a new standard for longitudinal studies has been established.

Since its first launch in the beginning of 2001, the minispec Live Mice Analyzer (LF50) has quickly gained market acceptance as a powerful, non-destructive and non-invasive mice analysis tool for characterizing, screening and mouse phenotyping in research laboratories. It has become the industrial standard for fat and lean measurement in live mice with installations in major pharmaceutical companies, diabetes and obesity research institutes and universities.

Nuclear Magnetic Resonance (NMR) methods are among the most useful non-destructive techniques of material analysis. Non-invasive examination of the body by means of NMR is extensive and has many useful applications, particularly with Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS). TD-NMR uses similar NMR technology, providing analysis of fat tissue, lean tissue and free fluid by the same physical selection rules that give rise to contrast in MRI. Tissue contrast is high between fat and muscle based on relative relaxation times.

The minispec Body Composition Analyzer is based on Time Domain NMR. It acquires and analyzes TD-NMR signals from all protons in the entire sample volume and can provide 3 components of interest: Fat, Free Body Fluid and Lean Tissue values.

This Magnetic Resonance technology provides researchers with the opportunity to make multiple measurements during the life of the animal with the following benefits:

• Rapid analysis: measurement takes less than 2 minutes, no sample preparation
• Economical procedures: no consumables, retain expensive lab animals for entire study
• LF50 for mice analyzes animals up to 60 g
• LF50H for mice analyzes animals up to 60 g
• LF90II for mice and rats analyzes animals up to ~ 700 g
• LF110 for mice and rats analyzes animals up to approximately 1 kg
• Reduced animal stress: no need for anesthetics; animals are measured “as-is”
• Allows more frequent testing, due to reduction of risks to animal health
• Better accuracy and precision compared to DEXA (X-ray) method

Body Composition Analysis of Mice and Rats

Bruker’s minispec Whole Body Composition Analyzer based on TD-NMR provides a precise method for measurement of lean tissue, fat and fluid in living mice and rats.

This body composition analyzer boasts a novel and striking key feature: Because the animal is carefully handled without using any anesthetics, a new standard for longitudinal studies has been established.

Since its first launch in the beginning of 2001, the minispec Live Mice Analyzer (LF50) has quickly gained market acceptance as a powerful, non-destructive and non-invasive mice analysis tool for characterizing, screening and mouse phenotyping in research laboratories. It has become the industrial standard for fat and lean measurement in live mice with installations in major pharmaceutical companies, diabetes and obesity research institutes and universities.

Nuclear Magnetic Resonance (NMR) methods are among the most useful non-destructive techniques of material analysis. Non-invasive examination of the body by means of NMR is extensive and has many useful applications, particularly with Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS). TD-NMR uses similar NMR technology, providing analysis of fat tissue, lean tissue and free fluid by the same physical selection rules that give rise to contrast in MRI. Tissue contrast is high between fat and muscle based on relative relaxation times.

The minispec Body Composition Analyzer is based on Time Domain NMR. It acquires and analyzes TD-NMR signals from all protons in the entire sample volume and can provide 3 components of interest: Fat, Free Body Fluid and Lean Tissue values.

This Magnetic Resonance technology provides researchers with the opportunity to make multiple measurements during the life of the animal with the following benefits:

• Rapid analysis: measurement takes less than 2 minutes, no sample preparation
• Economical procedures: no consumables, retain expensive lab animals for entire study
• LF50 for mice analyzes animals up to 60 g
• LF50H for mice analyzes animals up to 60 g
• LF90II for mice and rats analyzes animals up to ~ 700 g
• LF110 for mice and rats analyzes animals up to approximately 1 kg
• Reduced animal stress: no need for anesthetics; animals are measured “as-is”
• Allows more frequent testing, due to reduction of risks to animal health
• Better accuracy and precision compared to DEXA (X-ray) method

Body Composition Analysis of Mice and Rats

Bruker’s minispec Whole Body Composition Analyzer based on TD-NMR provides a precise method for measurement of lean tissue, fat and fluid in living mice and rats.

This body composition analyzer boasts a novel and striking key feature: Because the animal is carefully handled without using any anesthetics, a new standard for longitudinal studies has been established.

Since its first launch in the beginning of 2001, the minispec Live Mice Analyzer (LF50) has quickly gained market acceptance as a powerful, non-destructive and non-invasive mice analysis tool for characterizing, screening and mouse phenotyping in research laboratories. It has become the industrial standard for fat and lean measurement in live mice with installations in major pharmaceutical companies, diabetes and obesity research institutes and universities.

Nuclear Magnetic Resonance (NMR) methods are among the most useful non-destructive techniques of material analysis. Non-invasive examination of the body by means of NMR is extensive and has many useful applications, particularly with Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS). TD-NMR uses similar NMR technology, providing analysis of fat tissue, lean tissue and free fluid by the same physical selection rules that give rise to contrast in MRI. Tissue contrast is high between fat and muscle based on relative relaxation times.

the minispec Body Composition Analyzer is based on Time Domain NMR. It acquires and analyzes TD-NMR signals from all protons in the entire sample volume and can provide 3 components of interest: Fat, Free Body Fluid and Lean Tissue values.

This Magnetic Resonance technology provides researchers with the opportunity to make multiple measurements during the life of the animal with the following benefits:

• Rapid analysis: measurement takes less than 2 minutes, no sample preparation
• Economical procedures: no consumables, retain expensive lab animals for entire study
• LF50 for mice analyzes animals up to 60 g
• LF50H for mice analyzes animals up to 60 g
• LF90II for mice and rats analyzes animals up to ~ 700 g
• LF110 for mice and rats analyzes animals up to approximately 1 kg
• Reduced animal stress: no need for anesthetics; animals are measured “as-is”
• Allows more frequent testing, due to reduction of risks to animal health
• Better accuracy and precision compared to DEXA (X-ray) method

Key Advantages

1. Single supplier solution: minispec and Sample Automation system both provided by Bruker BioSpin.
2. SFC Sample Automation system automatically and accurately controls tempering times delivering results in strictest accordance to SFC International Standard Methods.
3. Automation for all other major Time Domain-Nuclear Magnetic Resonance (TD-NMR) minispec applications including the following preparation steps:
   – Sample pre-tempering (heating)
   – Barcode reader option
4. Service and support by Bruker BioSpin or local representative

Technical Details

The minispec Sample Automation Offers a New Dimension in Options

Sample Automation Set-up

• x-y-z sample changer mounted on a robust platform that can hold minispec, racks, tempering devices (optional, depending on application)
• TÜV approved and conform to European, American and Canadian regulations (with and without safety housing)
• Optional (but recomended) safety housing including sliding doors and locks. This option furthermore features an emergency stop button.

Quick and Convenient Sample Insertion

• Input and output racks with sensors that detect tray status (software supported)
• Special versions of trays adapted for the SFC application
• The software can handle the two trays as combined or separate input/output blocks

Tempering Options/Further Assemblies

• Heating and cooling devices based on Peltier Technology
• SFC tempering blocks: ±0.1°C precision
• Heating only devices available
• Max. temperature range: 0 … 100°C
• Handles with up to 6 measurement temperatures (optional)
• Tempering devices are also available without sample changer
• Barcode reader (optional)

Increasing TD-NMR Efficiency With the New theminispec Sample Automation Software

The minispec Sample Automation software is a feature-packed easy-to-use solution that provides significant flexibility, usability and the performance required to maximize your lab efficiency by automating your TD-NMR minispec applications.

Its practical software design and dedicated feature options include:

• Existing customer TD-NMR methods are easily added and implemented
• Different TD-NMR methods can all run simultaneously
• Sample priorities can be assigned
• Choice of rack combinations with in-position/out-of-position sensor
• Error management highlights errors by adding colors to the results

theminispec Sample Automation Software

• Automated Daily Check function ensures consistent operation
• Automatic plotting of bath temperatures
• Accurate monitoring of tempering times and temperatures with out-of-limit warnings
• All common International Standard Methods are supported
• Graphical display of data with calculation options and error handling
• PC controlled: Windows 7 / 32 or 64 bit Software

The minispec mq-one is the right choice

The mq-one analyzer is not just a benchtop system or mini NMR system; it is a dedicated analyzer providing a complete solution off the shelf. With easy installation, comprehensive calibration and calibration transfer standards, the mq-one is ready for use within minutes. This approach is a result of Bruker`s extensive experience in these dedicated applications.

Ready-to-go

The minispec mq-one analyzers come complete, ready-to-install, with calibration standards and traceable multi-language software. The installation instructions can get easier than this: place the mq-one on your lab bench, connect only two cables: the Ethernet cable to your PC and the power cord, switch it on and in 30 seconds the mq-one is operational.

Better for your Laboratory

Nowadays, laboratory space is precious. The current version of minispec mq-one has a smaller footprint than its predecessor, thus requiring less valuable space on your laboratory bench. Moreover, the mq-one is a quiet-runner, its low decibel operation noise will keep your laboratory quiet. Plus this machine with its maintenance-free ventilation concept requires only comparatively small amounts of electricity (ISO 14001), thus keeping down operating costs.-install, with calibration standards and traceable multi-language software. The installation instructions can get easier than this: place the mq-one on your lab bench, connect only two cables: the Ethernet cable to your PC and the power cord, switch it on and in 30 seconds the mq-one is operational.

Performance You Can Rely On

Precise and long-term stable results can only be achieved with an optimal system layout. The mq-one with its all-in-one design perfectly matches these requirements. Both long-term and short-term measurement stabilities for the application of interest have continually been improved further. The system`s internal temperature is kept at a constant higher than room temperature (typically, but not limited to 40 °C) to within a 1/100 of a degree Celsius to guarantee optimal performance in a 24/7 operation.

minispec m+ Software

Since the introduction of the mq-series in 1998, the requirements for today`s industrial Quality Control (QC) have evolved. In order to provide solutions for today’s challenges, Bruker now offers the 21 CFR part 11 compliant minispec plus software for the mq-one analyzers. The minispec plus combines multilingual support, user administration, ease of use and an intuitive work-flow for both calibration and daily measurements.

Key features of the minispec mq series

• Multinuclear NMR and variable frequency 5 – 60 MHz
• Wide range of magnet fields plus a unique 60 MHz system
• Ethernet connection from PC to minispec electronic unit
• Remote control, system logging and daily check
• Bruker minispec application pool containing all standard and advanced applications
• Wide range of probe heads (absolute, ratio, combined, temperature controlled, gradients), temperature range: -100 to +200 °C
• Fast magnet warm-up and precise digital temperature regulation for ultimate stability of results
• Tool-free exchange of Plug-n-Play probes with auto-recognition
• Linear transmitter with digital pulse attenuation (optional)
• Highly linear fast signal detection
• Virtually unlimited number of pulses and echoes
• Pulsed field gradients (optional)
• Zero-maintenance units without direct air exchange
• Proven track record, long MTBF
• minispec application and service support